The genetic basis of rare mutations in Alzheimer’s disease

Familial Alzheimer’s disease (FAD), a rare inherited form of the condition, is associated with mutations in several genes, including APP, PSEN1, and PSEN2. While the role of PSEN2 mutations has been less understood, recent research led by Prof. Wim Annaert at VIB-KU Leuven has uncovered how mutated PSEN2 accelerates disease progression in FAD. Their findings provide new insights into the underlying mechanisms driving this genetic form of Alzheimer’s, enhancing our understanding of the disease and its progression.